Thread: Peptides, ghrp-6, cjc-1295 or ghrp-2, grf 1-29

Share This Thread!

• Share on Facebook

I have been trying to make sense of peps before a trial run and found this post informative
then after reading the bulk of it i found out someone had stolen it from datbtrue

Posted by dabtrue on another board:

GHRP-6, GHRP-2 and Hexarelin are all interchangeable. They are treated as interchangeable in the studies. They work via the same mode of action. Their slight differences are probably attributable to the different "batches" of non-pituitary neurons they excite. One peptide may excite one "batch" more or less than another.

Hexarelin is the strongest of the GHS peptides. It also induces higher amounts of cortisol & prolactin then the other peptides. It may (according to one comparison study) desensitize quicker. GHRP-2 is a little less strong with less impact on cortisol & prolactin. GHRP-6 has very little impact on cortisol & prolactin (although it is a little elevated above 1mcg/kg dosing) and is a little less stronger than GHRP-2.

So you could choose whichever is cheaper. I know GHRP-6 & GHRP-2 cost the same to make. However GHRP-6 at the moment at retail level is a lot cheaper...

There is no direct benefit to combining GHRPs because they all act through the same mode of action. You just choose one and run it from the saturation dose of 100mcg up to the maximally beneficial dose (which would be 300mcg - 400mcg) at each administration.

I know on the web you see old posts where people talk about the positive effect of combining Hex & GHRP-6. Thats just incorrect. What you do is make a decision on how much GHS you want to run and then choose among the GHS (GHRP-2, GHRP-6, Hexarelin, Ipamorelin). If you choose to use 300mcg you could use half (150mcg) of GHRP-2 and half GHRP-6 OR use Hexarelin , GHRP-2, GHRP-6 in equal thirds to fill that 300mcg dose slot.

However there is no synergy between these GHRPs and no advantage to dosing in total above 300 - 400mcg.

The GHRPs (GHRP-6, etc.) should ALWAYS be dosed at bed if you can (if you miss a dose no big deal). Depending on what study you read upto 85% of GH release in males occurs in that night-time (just after you fall asleep) pulse/spike. A dose of GHRP-6 of any amount will amplify that pulse which will give you more GH for the night. Looking at the study charts it appears that the pulse ends up being 2x to 6x higher than normal. Optimal dosage is 100mcg upto 300mcg - 400mcg. I've experimented with all doses and found 100mcg to be just fine BUT I do notice even deeper sleep at 200 & 300mcg dosing.

Keep in mind that glucose and fatty acids blunt (but don't eliminate) GHRPs induced GH release. The peak of the pulse occurs 30 minutes after dosing GHRPs so optimally take the dose on an empty stomach and wait 30 minutes before eating. This doesn't have to be exact...just the way to maxamize the pulse secretion. GHRPs can be analogized to a non-estered testosterone such as Test-suspension. You take it...you get the effect...then its gone.

CJC-1295 on the other hand is long-lasting. Most people are dosing it twice per week... That means no matter where you are or what you're doing throughout the week you have elevated levels of GH in your body. CJC-1295 can be analogized to a longer-estered testosterone such as enanthate.

Most are dosing it at 2mg per week split in two doses because that is what the CJC study in humans used (actually close to the mimimal dose of that study) and because these are bodybuilders tring to maxamize GH. But IF they used GHRP-6 a few times a day they could get an even higher amount of GH release or....

...if you are a 42 year old guy like me...and you understand that CJC-1295 = GHRH...and 100mcg of GHRH combined with 100-300mcg of GHRP-6 is hugely synergetic...and you are only trying to achieve a really good GH level then you experiment. It is now very well established throughout a body of research spanning more than a decade that includes more than thirty studies in humans that there is huge synergy in vivo between Growth hormone releasing hormone (GHRH) (of which CJC-1295 is a long-lasting analog) and Growth hormone releasing peptides (GHRP-6, GHRP-2, Hexarelin, Ipamorelin).

I experimented with just one dose of 100mcg CJC-1295 before bed...plus my 3x per day GHRP-6 dosing. I did this daily which meant 700mcg was used per week. That became my standard dosing scheme.

However, for the last three weeks I have been on an anabolic cycle (test, t3, slin) and wanted high GH levels. So my dosing protocol has been 100mcg CJC-1295 3x per day and GHRP-6 (100mcg-200mcg) dosed with it 3 x per day. That equates to 2100mcg of CJC-1295. I am finding this to amount to a high level of GH & to be hugely synergistic w/ the test & slin.

So my base level of GH stays elevated, IGF-1 stays elevated and when I add the GHRP-6 I induce a two hour amplified pulse of GH release which is great for growth. My dosing creates a pulse in the morning, post-work out and pre-bed.

so here is what I am thinking

ghrp-6 100mcg 2-3x day (morning, post workout, bedtime)
cjc-1295 100mcg 1x day (bedtime)

(currently on 400mg test cyp and 300eq a week)

and reconstituting
the ghrp-6 is 5mg so adding 2.5ml bac water makes it 20mcg/tic so 5 tics a shot for @20 days
The cjc-1295 is 2mg so adding 1ml bac water makes it 20mcg/tic so 5 tics a shot for 20 days

it looks like 2 bottles of each 40 days, so about $80,

cost wise 2iu/day generic is twice as expensive,
I wonder if the results are dramatically better than that much straight GH
the dosing is obviously more intensive

Thanks for the info man,

The cjc is labeled "Mod Grf 1-29 aka CJC-1295"

I can grab -2 instead of -6 easy, thanks again
i dont need the hunger, trying to stay lean or get leaner

I was wondering about the pre-post workout because i work out from 6-8:30pm then go to bed about 10pm
so post workout and before bed kinda doesn't work for me. I am glad i can use pre-workout, that makes more sense with my schedule



I feel 100% safe of the quality of the product i am looking at
many people i talk to on them and reporting positive feedback

Stolen from Aware who stole from Dat's
just trying to keep all my info in one place

Which GHRP?

GHRP-6 is sloppier in that it activates a wider array of effects beyond GH release. It causes intense hunger and gastic motility. It can have a mild effect on cortisol and prolactin. It is a first generation GHRP.

GHRP-2 is less sloppy with a more intense GH release, no gastric motility and less hunger effect. It can have an effect within the normal range on prolcatin and cortisol. It is a second generation peptide.

Ipamorelin is not sloppy at all. It does not release as much GH as GHRP-2 but it causes virtually no hunger or gastric motility and for the most part does not effect cortisol or prolactin. It is a third generation peptide

You would choose GHRP-2 unless you wanted GHRP-6 for the hunger effect or for the lower release profiles.

You would choose GHRP-2 normally as the most bang for the buck.

If you are very sensitive to perturbations in cortisol or prolactin you would choose the more expensive Ipamorelin.

stolen again

Which GHRH?

The body makes GHRH which 44 aminos long. 15 amino acids are useless so the first 29 amino acids is what is known as GRF(1-29). Yes GHRH(1-29) makes more sense but someone chose G for "growth hormone", R for "releasing" and F for "factor". The numbers just tell you which amino acids from GHRH are kept.

GRF(1-29) acts just like GHRH so I'll color it green. GRF(1-29) is an FDA-approved pharmaceutical drug named Sermorelin.

So GHRH, GRF(1-29) and Sermorelin are basically the same. The problem though is they are easily eaten up by blood enzymes within minutes. If you could inject directly into the pituitary at the base of the brain then they will be effective, after-all that is what the brain drops into the pituitary. But circulating in the blood means they are rendered ineffective within minutes.

That leaves us with analogs. An analog is a modification(s) to the peptide such that a property(ies) is(are) changed such as longer half-life, receptor binding affinity or receptor binding strength w/o losing the action. Many analogs can and have been made. However all you need is an analog that survives early blood plasma enzyme death and lasts say 30 minutes. Note a receptor is how some hormones/peptides interact with a cell. The hormone/peptide binds to a receptor on the outside of the cell and the message carried in. I purposely avoided receptor talk so as to avoid confusion and substituted the term "contact" and "contact with the cell".

IGF-1 LR3 is an analog of IGF-1. It survives longer in plasma w/o binding to a binding protein but also has a lower binding affinity for its contact with the cell or better yet IGF-receptor.

CJC is a term coined & used in a study that tested a newly created velcro type drug complex to attach to GRF(1-29) to allow it to cling to albumin in blood and give it protection and a long life (albumin has a very long plasma life).

They tested three peptides/drug compounds. The first was simply GRF(1-29) with the drug affinity complex (DAC) attached. Think of that DAC as simply the velcro drug component. As you can see the CJCs are not pure peptides. They called this CJC-1288. It lasted about the same as plain old GRF(1-29). Blood plasma enzymes killed it in minutes.

Then they took GRF(1-29) and made one amino acid swap plus the DAC (velcro drug) That means they took Arginine in the 2nd position of the peptide and replaced it with its mirror image form known as the D form. This makes the analog peptide stronger but not by enough. The half-life is maybe double GRF(1-29) in humans. So 5 minutes of half-life. This they called CJC-1293.

Then they made 4 amino acid changes in GRF(1-29) to really strengthen it so it would last more then 30 minutes and added the drug affinity complex. This worked well for them because the peptide/drug hybrid lasted long enough to find the plasma albumin for the DAC part to velcro itself to for a long life of several days. This they called CJC-1295

You want none of the CJC's. The first two because they do not survive long enough and the last one because it is always around. True somatostatin does pop up and stop GH release, but as soon as it can CJC-1295 is inducing GH release. The study itself found it increased base levels but did not increase pulses. That means there is less GH mass synthesized and stored in the somatotrophs. What are somatotrophs? Remember they are growth hormone releasing cells. The word may sound like somatostatin but only somatostatin has the power to stop GH release because? Because it is colored in red.

Somatotrophs are not cells that release prolactin. Prolactin is released by Lactotrophs. Somatotrophs self organize into networks that coordinate GH release into a pulse. A fuller treatment is available on this forum.

What do you want?

[u]You want the pure peptide part that was used in the third analog. You want those 4 modifications because they make what is essentially GHRH last for 30 minutes or more. This is a fine peptide to contribute to a GH pulse. This I call modified GRF(1-29). Since it is basically a 30 minute plus lasting GHRH I color it green.

just gathering information all in one place

Straight GH would be easier to run

I have heard mention a couple times of $1/iu. That must be cheap generics which also have the problem you are talking about with getting crap
Twice in the last 4-5 months guys online have tested GH kits and found them to contain nothing
so what I am hearing online is to stick to a couple reputable brand names and they are not $1/iu. Moore like 1.8-2.0
or maybe your talking ordering from overseas prices, i let someone else take the customs hit and only order domestic.

I am going to try both and see the results first hand
peps were cheaper and i am broke right now so i tried them first

I am only about a week in so hard to say what results i am seeing if any
I would say my appetite is up for sure and sleep seems good
but joints still hurt and not really leaning out yet
but like i said its only a week